5.05723
SCH 23390 Hydrochloride
别名:
SCH 23390 Hydrochloride, Dopamine Receptor D1/D5 Antagonist, SCH 23390, (R)-(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine Hydrochloride, SCH23390, SCH-23390
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经验公式（希尔记法）:
C17H18ClNO · xHCl
化学文摘社编号:
分子量:
287.78 (free base basis)
UNSPSC Code:
12352200
MDL number:
InChI
1S/C17H18ClNO.ClH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H/t15-;/m1./s1
InChI key
OYCAEWMSOPMASE-XFULWGLBSA-N
assay
≥99% (HPLC)
form
solid
potency
0.2 nM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
water: 100 mM
storage temp.
−20°C
Quality Level
General description
A highly potent and selective dopamine D1-like receptor antagonist with a Ki of 0.2 and 0.3 nM for the D1 and D5 dopamine receptor subtypes, respectively. Also an agonist at 5-HT1C and 5-HT2C receptors in vitro (Ki values are 6.3 nM and 9.3 nM respectively).
Biochem/physiol Actions
Primary Target
D1 and D5
D1 and D5
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Splinter, M. Y. 2007. Ann. Pharmacother.41, 285.
Pfeiffer, R. F. 2002. Drugs Aging.19, 561.
Pfeiffer, R. F. 2002. Drugs Aging.19, 561.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
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Maria C Tickerhoof et al.
Psychoneuroendocrinology, 113, 104542-104542 (2019-12-22)
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