5.05736
5-BDBD
别名:
5-BDBD, 5-(3-Bromophenyl)-1,3-dihydro-2H-Benzofuro[3,2-e]-1,4-diazepin-2-one, P2X4 Purinergic Receptor Antagonist, 5-BDBD
方案
≥99% (HPLC)
质量水平
表单
powder
效能
500 nM IC50
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
off-white
溶解性
DMSO: 15 mg/mL
储存温度
2-8°C
InChI
1S/C17H11BrN2O2/c18-11-5-3-4-10(8-11)15-17-16(20-14(21)9-19-15)12-6-1-2-7-13(12)22-17/h1-8H,9H2,(H,20,21)
InChI key
NKYMVQPXXTZHSF-UHFFFAOYSA-N
一般描述
A highly potent antagonist of purinergic P2X4 receptor. Shown to block P2X4-mediated currents in Chinese hamster ovary cells (IC50 = 500 nM). Blocks ATP-induced dilation of spiral ligament capillaries in guinea pigs. Also shown to restore the viability of activated CD4+ cells in the presence of 1 mM ATP.
生化/生理作用
Primary Target
P2X₄
P2X₄
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Trabanelli, S., et al. 2012. J. Immunol.189, 1303.
Wu, T., et al. 2011. Am. J. Physiol.301, H69.
Wu, T., et al. 2011. Am. J. Physiol.301, H69.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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