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Merck
CN

5.05771

4-DAMP

别名:

4-DAMP, 1,1-Dimethyl-4-diphenylacetoxypiper­idinium iodide, Muscarinic Receptor Antagonist, 4-DAMP

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关于此项目

经验公式(希尔记法):
C21H26INO2
化学文摘社编号:
分子量:
451.34
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
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assay

≥98% (HPLC)

Quality Level

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white to off-white

solubility

DMSO: 100 mM, ethanol: 25 mM

storage temp.

2-8°C

InChI

1S/C21H26NO2.HI/c1-22(2)15-13-19(14-16-22)24-21(23)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18;/h3-12,19-20H,13-16H2,1-2H3;1H/q+1;/p-1

InChI key

WWJHRSCUAQPFQO-UHFFFAOYSA-M

General description

An antagonist selective for mAChRs (Ki = 0.57, 7.3, 0.37, 0.72 and 0.55 nM at human M1, M2, M3, M4, and M5 receptors respectively). Used frequently in investigating the functional roles of M1 and M3 receptors in both central and peripheral nervous systems.

Biochem/physiol Actions

Primary Target
Muscarinic Receptors
Target Ki: 0.57, 7.3, 0.37, 0.72 and 0.55 nM at human M1, M2, M3, M4, and M5 receptors respectively

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Kruse, C., et al., 2012. Nature.482, 552.
Moriya, H., et al., 1999. Life Sci.64, 2351.
Ehlert, J., 1996. Life Sci.58, 1971.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)


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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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