5.05773
Bethanechol Chloride
别名:
Carbamyl-β-methylcholine chloride, Carbamyl-β-methylcholine chloride, Muscarinic Acetylcholine Receptors (mAChR) Agonist, Bethanechol Chloride, Bethanechol chloride
color
white
InChI key
AIRHOJQHGLTTTB-UHFFFAOYSA-N
InChI
1S/C7H17N2O2.ClH/c1-6(11-7(8)10)5-9(2,3)4;/h6H,5H2,1-4H3,(H2,8,10);1H
SMILES string
Cl.CC(C[N](C)(C)C)OC(N)=O
assay
≥98% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
solubility
water: 100 mM
Quality Level
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General description
An agonist selective for Muscarinic Acetylcholine Receptors (mAChRs, EC50 = 7, 14.5, 35 and 32 µM for M4, M3, M1 and M5 respectively) with no effect on nicotinic receptors. It is not a substrate for acetylcholinesterase therefore has longer duration of action than acetylcholine. Clinically used to treat certain bladder related conditions.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Manchana T., et al., 2011. Int. J. Gynecol. Cancer.21, 730.
Liu, L., et al. 2003. Br. J. Pharmacol.138, 70.
Liu, L., et al. 2003. Br. J. Pharmacol.138, 70.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
法规信息
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