方案
≥99% (HPLC)
质量水平
表单
solid
效能
7.1 nM Ki
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: soluble
储存温度
2-8°C
InChI
1S/C20H21ClN2O/c21-17-7-5-16(6-8-17)20(24)9-11-23(12-10-20)14-15-13-22-19-4-2-1-3-18(15)19/h1-8,13,22,24H,9-12,14H2
InChI key
LLBLNMUONVVVPG-UHFFFAOYSA-N
一般描述
Selective dopamine D2 receptor antagonist that is shown to reversibly block agonist-induced activation of GIRK currents. Reported to have a 15-fold selectivity for D2R over D3R in vitro. Inhibition of 3H-spirperone binding to cloned rat Dopamine receptors show the following Ki values: D2R (7.1 nM), D3R (155 nM), D4R (596 nM). Commonly used D2 inhibitor in addiction research.
生化/生理作用
Primary Target
D₂
D₂
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Grundt, P. et al. 2007. Bioorg. Med. Chem. Lett.17, 745.
Caine, S. B. et al. 2002. J. Neurosci.22, 2977.
Pillai, G. et al. 1998. Neuropharmacol.337, 983.
Caine, S. B. et al. 2002. J. Neurosci.22, 2977.
Pillai, G. et al. 1998. Neuropharmacol.337, 983.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持