InChI key
QIIVUOWTHWIXFO-UHFFFAOYSA-N
InChI
1S/C8H20NO4P/c1-3-12-8(13-4-2)14(10,11)7-5-6-9/h8H,3-7,9H2,1-2H3,(H,10,11)
assay
≥98% (TLC)
form
solid
potency
34 μM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
water: 100 mM
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Primary Target
GABAB
GABAB
Disclaimer
Toxicity: Standard Handling (A)
General description
A selective antagonist of post-synaptic GABAB receptors (IC50 = 34 µM) that can permeate the blood brain barrier. Exhibits about 10-fold lower affinity for pre-synaptic receptors. Blocks K+-evoked glycine exocytosis in mouse spinal cord and hippocampal nerve endings. Shown to antagonize the potentiating effect of L-baclofen on noradrenaline-induced stimulation of adenylate cyclase in rat cortex slices.
Other Notes
Romei, C., et al., 2010. Pharmacol. Res.61, 547.
Staubli, U., et al., 1999. J. Neurosci.19, 4609l.
Olpe, H.R., et al. 1990. Eur. J. Pharmacol.187, 27.
Staubli, U., et al., 1999. J. Neurosci.19, 4609l.
Olpe, H.R., et al. 1990. Eur. J. Pharmacol.187, 27.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
wgk
WGK 3
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持