方案
≥98% (TLC)
质量水平
表单
solid
效能
34 μM IC50
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
water: 100 mM
储存温度
−20°C
InChI
1S/C8H20NO4P/c1-3-12-8(13-4-2)14(10,11)7-5-6-9/h8H,3-7,9H2,1-2H3,(H,10,11)
InChI key
QIIVUOWTHWIXFO-UHFFFAOYSA-N
一般描述
A selective antagonist of post-synaptic GABAB receptors (IC50 = 34 µM) that can permeate the blood brain barrier. Exhibits about 10-fold lower affinity for pre-synaptic receptors. Blocks K+-evoked glycine exocytosis in mouse spinal cord and hippocampal nerve endings. Shown to antagonize the potentiating effect of L-baclofen on noradrenaline-induced stimulation of adenylate cyclase in rat cortex slices.
生化/生理作用
Primary Target
GABAB
GABAB
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Romei, C., et al., 2010. Pharmacol. Res.61, 547.
Staubli, U., et al., 1999. J. Neurosci.19, 4609l.
Olpe, H.R., et al. 1990. Eur. J. Pharmacol.187, 27.
Staubli, U., et al., 1999. J. Neurosci.19, 4609l.
Olpe, H.R., et al. 1990. Eur. J. Pharmacol.187, 27.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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