5.05982
(-)-Quinpirole Hydrochloride
别名:
(-)-Quinpirole Hydrochloride, Dopamine D2 Receptor Agonist, Quinpirole, Quinpirole, LY-171,555, LY 171555
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关于此项目
经验公式（希尔记法）:
C13H21N3 · xHCl
化学文摘社编号:
分子量:
219.33 (free base basis)
UNSPSC Code:
12352200
MDL number:
InChI
1S/C13H21N3.ClH/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12;/h9-10,13H,2-8H2,1H3,(H,14,15);1H/t10-,13-;/m1./s1
InChI key
HJHVRVJTYPKTHX-HTMVYDOJSA-N
assay
≥98% (HPLC)
form
powder
potency
4.8 nM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
water: 7.3 mg/mL
storage temp.
−20°C
Quality Level
General description
A potent, selective dopamine D2 receptor agonist with a Ki value of 4.8 nM. Some D3(Ki = 24 nM) and D4 (Ki = 30 nM) receptor agonistic action has also been reported. In rat striatum studies in vitro, application of quinpriole inhibited single pulse dopamine overflow in a concentration-dependent manner (IC50 = 32.5 nM).
Other Notes
OʹNeill, C. et al. 2009. J. Neurochem.108, 545.
Malmberg, A. and Mohell, N. 1995. J. Pharmacol. Exp. Ther.274, 790.
Seeman, P. and Schaus, J. M. 1991. Eur. J. Pharmacol.203, 105.
Malmberg, A. and Mohell, N. 1995. J. Pharmacol. Exp. Ther.274, 790.
Seeman, P. and Schaus, J. M. 1991. Eur. J. Pharmacol.203, 105.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
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