5.05983
NS1738
别名:
NS1738, 1-(5-chloro-2-hydroxyphenyl)-3-(2-chloro-5-(trifluoromethyl)phenyl)urea, α7 nAChR positive allosteric modulator, NS1738, NS 1738, NS-1738
方案
≥99% (HPLC)
质量水平
表单
powder
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
beige
溶解性
DMSO: 100 mg/mL
储存温度
2-8°C
InChI
1S/C14H9Cl2F3N2O2/c15-8-2-4-12(22)11(6-8)21-13(23)20-10-5-7(14(17,18)19)1-3-9(10)16/h1-6,22H,(H2,20,21,23)
InChI key
OUDXRNQPVSMGDW-UHFFFAOYSA-N
一般描述
A biarylurea derivative that acts as a selective positive allosteric modulator selective for α7 nicotinic acetylcholine receptors (α7 nAChR) without substantial activity for α4β2, α3β3 and α1-containing receptors. Exhibits cognitive enhancing effects in vivo.
生化/生理作用
Primary Target
α7 AChR
α7 AChR
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Freitas, K., et al., 2013. J. Pharmacol. Exp. Ther.344, 264.
Timmermann, B., J. et al., 2007, Pharmacol. Exp. Ther.323, 294.
Faghih, R., 2007. Recent Pat CNS Drug Discov.2, 99.
Timmermann, B., J. et al., 2007, Pharmacol. Exp. Ther.323, 294.
Faghih, R., 2007. Recent Pat CNS Drug Discov.2, 99.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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