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Merck
CN

506156

p38 MAP Kinase Inhibitor V

The p38 MAP Kinase Inhibitor V, also referenced under CAS 271576-77-3, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

别名:

p38 MAP Kinase Inhibitor V, 4-(3-(4-Chlorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)pyrimidine, SC-409

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关于此项目

经验公式（希尔记法）:
C19H20ClN5
化学文摘社编号:
271576-77-3
分子量:
353.85
UNSPSC Code:
12352200
Assay:
≥90% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light

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InChI key

WYWOBCJMDNZHAV-UHFFFAOYSA-N

InChI

1S/C19H20ClN5/c1-25-10-7-14(8-11-25)19-17(16-6-9-21-12-22-16)18(23-24-19)13-2-4-15(20)5-3-13/h2-6,9,12,14H,7-8,10-11H2,1H3,(H,23,24)

assay

≥90% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

light yellow

solubility

DMSO: 10 mg/mL, ethanol: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

General description

A cell-permeable trisubstituted pyrazole compound that acts as a highly potent ATP-competitive inhibitor of CK1δ and p38α (IC50 = 20 and 40 nM, respectively). Shown to affect p38β, PKA, JNK2, and JNK3 activity (IC50 = 2.3, 10.5, 19.7, and 69.7 µM, respectively) only at much higher concentations and exhibit little effect against a panel of 44 other commonly studied kinases, including p38δ/γ, even at a conentraion of 10 µM or higher. An excellent tool for studying p38-mediated responses both in cells in vitro and in animals in vivo.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
p38 MAP Kinase
Product competes with ATP.
Reversible: no
Target IC50: 20 and 40 nM, against CK1δ and p38α, respectively

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Mbalaviele, G., et al. 2006. J. Pharm. Exp. Ther.317, 1044.
Liu, Y.H., et al. 2005. J. Card. Fail.11, 74.
Yu, J.J., et al. 2003. J. Immunol.171, 6112.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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相关内容

Human Kinome & InhibitorSelect™ Libraries

Human Kinome Poster: The InhibitorSelect™ Protein Kinase Inhibitor Libraries provide broad coverage of the human kinome as shown here. The depicted human kinome dendrogram of 518 kinases are classified into five broad groups, 90 families, and 145 subfamilies. Inhibitor coverage was assigned based upon published data related to potency (IC50, EC50, Kd, etc.) for individual kinases harvested from the literature. Colored dots denote which library contains an inhibitor with demonstrated potent activity against the designated kinase and do not necessarily reflect known specificity of the inhibitor. Coverage of lipid and atypical kinases are depicted as a separate dendrogram. As shown, Calbiochem® Protein Kinase Inhibitor Libraries cover all major kinase families including TK, CMGC, CAMK, AGC, CK1, STE, TKL, as well as Lipid or Atypical kinase families.

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