506157
p38 MAP Kinase Inhibitor VI, JX401
The p38 MAP Kinase Inhibitor VI, JX401, also referenced under CAS 349087-34-9, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
p38 MAP Kinase Inhibitor VI, JX401, N-(2-Methoxy-4-thiomethyl)benzoyl-4-benzylpiperidine
InChI key
OMGLGPKQUFSRNN-UHFFFAOYSA-N
InChI
1S/C21H25NO2S/c1-24-20-15-18(25-2)8-9-19(20)21(23)22-12-10-17(11-13-22)14-16-6-4-3-5-7-16/h3-9,15,17H,10-14H2,1-2H3
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
ethanol: 17 mg/mL, DMSO: 26 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
A cell-permeable piperidinamide compound that acts as a reversible and highly potent inhibitor of MAPK p38α (IC50 = 32 nM) with no detectable activity against p38γ even at concentrations as high as 10 µM. Shown to effectively block the differentiation of L8 myoblasts to myotubes at 10 µM in a reversible manner. Not a competitive inhibitor with respect to either ATP or substrate.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Friedmann, Y., et al. 2006. Mol. Pharmacol.70, 1395.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Regulatory Review (Z)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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