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5.06188

Sertraline Hydrochloride

Name: Sertraline Hydrochloride
Brand: MM

别名:

Sertraline Hydrochloride, Serotonin (5-HT) Reuptake Inhibitor, Sertraline, Zoloft

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关于此项目

经验公式（希尔记法）:

C₁₇H₁₇Cl₂N · xHCl

化学文摘社编号:

79559-97-0

分子量:

306.23 (free base basis)

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00895772

Assay:

≥99% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

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属性

assay

≥99% (HPLC)

Quality Level

100

form

solid

potency

3.3 nM K_i

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 100 mM, ethanol: 50 mM

storage temp.

2-8°C

SMILES string

[Cl-].Clc1c(ccc(c1)[C@@H]2CC[C@@H](c3c2cccc3)[N+H2]C)Cl

InChI

1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1

InChI key

BLFQGGGGFNSJKA-XHXSRVRCSA-N

说明

General description

A very potent uptake inhibitor highly selective for serotonin (K_i = 3.3 nM). Clinically prescribed as an antidepressant drug. Often used in studying major depressive disorders.

Biochem/physiol Actions

Primary Target
5-HT uptake transporter

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Brunoni, R., et al. 2013. JAMA Psychiatry.70, 383.

Kobayashi, K., et al. 1995. Br. J. Clin. Pharmacol.40, 481.
Heym, J., et al. 1988. J. Clin. Psychiatry.49 Suppl, 40.
Koe, K., et al. 1983. J. Pharmacol. Exp. Ther.226, 700.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

signalword

Warning

pcodes

P260 - P264 - P273 - P301 + P312 - P314 - P391

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c