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About This Item
经验公式（希尔记法）:
C3H9NO7P2 · 2Na · 5H2O
CAS Number:
分子量:
369.11
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
Product Name
Pamidronate, Disodium Salt, A potent and specific inhibitor of bone resorption that does not cause any significant detrimental effect on bone growth and mineralization at concentrations used.
质量水平
描述
Merck USA index - 14, 7003
方案
≥98% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
颜色
white
溶解性
water: 10 mg/mL
运输
ambient
储存温度
−20°C
SMILES字符串
[Na+].[Na+].[P](=O)([O-])([O-])[C@@]([P](=O)([O-])O)(O)CC[N+H3].O.O.O.O.O
InChI
1S/C3H11NO7P2.2Na.5H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;;;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;5*1H2/q;2*+1;;;;;/p-2
InChI key
CZYWHNTUXNGDGR-UHFFFAOYSA-L
相关类别
一般描述
A calcium metabolism regulator. A potent and specific inhibitor of bone resorption at doses devoid of any significant detrimental effect on bone growth and mineralization. Effective in a variety of conditions characterized by pathologically enhanced bone turnover, including Paget′s disease, hypercalcemia of malignancy, osteolytic bone metastasis, and steroid-induced cell death in vitro. Provided in a hydrated form containing five molecules of water.
A potent and specific inhibitor of bone resorption that does not cause any significant detrimental effect on bone growth and mineralization at concentrations used. Effective in a variety of conditions characterized by pathologically enhanced bone turnover, including Paget’s disease, hypercalcaemia of malignancy, osteolytic bone metastasis, steroid-induced osteoporosis, and idiopathic osteoporosis. Inhibits breast cancer cell growth by inducing cell death in vitro. Provided in hydrated form, contains five molecules of water.
生化/生理作用
Cell permeable: no
Primary Target
Inhibitor of bone resorption
Inhibitor of bone resorption
Product does not compete with ATP.
Reversible: no
制备说明
Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
其他说明
Fromigue, O., et al. 2000. J. Bone Miner. Res.15, 2211.
Fitton, A., and McTravish, D. 1991. Drugs41, 289.
Fitton, A., and McTravish, D. 1991. Drugs41, 289.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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