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Merck
CN

506600

Sigma-Aldrich

Pamidronate, Disodium Salt

≥98% (HPLC), bone resorption inhibitor, solid

别名:

Pamidronate, Disodium Salt, 3-Amino-1-hydroxypropylidene-bisphosphonic Acid, 2Na, Pentahydrate

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关于此项目

经验公式（希尔记法）:
C3H9NO7P2 · 2Na · 5H2O
化学文摘社编号:
109552-15-0
分子量:
369.11
MDL编号:
MFCD01938386
UNSPSC代码:
12352200
NACRES:
NA.77

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产品名称

Pamidronate, Disodium Salt, A potent and specific inhibitor of bone resorption that does not cause any significant detrimental effect on bone growth and mineralization at concentrations used.

质量水平

100

描述

Merck USA index - 14, 7003

方案

≥98% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)

颜色

white

溶解性

water: 10 mg/mL

运输

ambient

储存温度

−20°C

SMILES字符串

[Na+].[Na+].[P](=O)([O-])([O-])[C@@]([P](=O)([O-])O)(O)CC[N+H3].O.O.O.O.O

InChI

1S/C3H11NO7P2.2Na.5H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;;;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;5*1H2/q;2*+1;;;;;/p-2

InChI key

CZYWHNTUXNGDGR-UHFFFAOYSA-L

相关类别

一般描述

A calcium metabolism regulator. A potent and specific inhibitor of bone resorption at doses devoid of any significant detrimental effect on bone growth and mineralization. Effective in a variety of conditions characterized by pathologically enhanced bone turnover, including Paget′s disease, hypercalcemia of malignancy, osteolytic bone metastasis, and steroid-induced cell death in vitro. Provided in a hydrated form containing five molecules of water.
A potent and specific inhibitor of bone resorption that does not cause any significant detrimental effect on bone growth and mineralization at concentrations used. Effective in a variety of conditions characterized by pathologically enhanced bone turnover, including Paget’s disease, hypercalcaemia of malignancy, osteolytic bone metastasis, steroid-induced osteoporosis, and idiopathic osteoporosis. Inhibits breast cancer cell growth by inducing cell death in vitro. Provided in hydrated form, contains five molecules of water.

生化/生理作用

Cell permeable: no
Primary Target
Inhibitor of bone resorption
Product does not compete with ATP.
Reversible: no

制备说明

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.

其他说明

Fromigue, O., et al. 2000. J. Bone Miner. Res.15, 2211.
Fitton, A., and McTravish, D. 1991. Drugs41, 289.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302,H319

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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María A Günther Sillero et al.
FEBS letters, 580(24), 5723-5727 (2006-10-03)
T4 RNA ligase catalyzes the synthesis of ATP beta,gamma-bisphosphonate analogues, using the following substrates with the relative velocity rates indicated between brackets: methylenebisphosphonate (pCH(2)p) (100), clodronate (pCCl(2)p) (52), and etidronate (pC(OH)(CH(3))p) (4). The presence of pyrophosphatase about doubled the rate

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