5.08120
GR113808
别名:
GR113808, 5-HT4 Serotonin Receptor Antagonist, GR113808, GR 113808, GR-113808
InChI
1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3
InChI key
MOZPSIXKYJUTKI-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
ethanol: 10 mM, DMSO: 100 mM
Quality Level
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General description
A potent and selective antagonist of the serotonin 5-HT4 receptor (pki = 9.3-10.3). GR113808 is commonly used in brain and peripheral in vitro and in vivo in striatum studies (Guinea pig IC50 = 113 nM, rat brain membrane Kd = 0.4-1 nM) and in cAMP response in CHO and C6 glial cells (EC50 = 79-81 nM).
Biochem/physiol Actions
Primary Target
5-HT₄
5-HT₄
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Johnson, D. E. et al. 2012. J. Pharmacol. Exp. Ther.112, 681.
Mine, Y. et al. 1997. J. Pharmacol. Exp. Ther.283, 1000.
Gale, J. D. et al. 1994. Br. J. Pharmacol.111, 332.
Mine, Y. et al. 1997. J. Pharmacol. Exp. Ther.283, 1000.
Gale, J. D. et al. 1994. Br. J. Pharmacol.111, 332.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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