5.08150
LY 344864 Hydrochloride
别名:
LY 344864 Hydrochloride, 5-HT 1F Serotonin Receptor Agonist, LY 344864, LY344864, LY-344864, 5-HT1F Serotonin Receptor Agonist, LY 344864, LY344864, LY-344864
storage temp.
2-8°C
InChI key
OKUHLSYESBLBCP-PKLMIRHRSA-N
InChI
1S/C21H22FN3O.ClH/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13;/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26);1H/t16-;/m1./s1
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
water: 10 mM, DMSO: 100 mM
Quality Level
General description
A selective, brain penetrant, full agonist for the 5-HT1F receptor (pKi = 8.2). It possesses little affinity for the 56 other serotonergic and non-serotonergic neuronal binding sites examined. When examined for its ability to inhibit forskolin-induced cyclic AMP accumulation in cells stably transfected with human 5-HT1F receptors, LY344864 was shown to be a full agonist producing an effect similar in magnitude to serotonin itself. Suitable for both in vitro and in vivo applications and its effects are often reversed with the 5-HT1B/1D antagonist GR 127935 (Cat. No. 508014)
Biochem/physiol Actions
Primary Target
5-HT1F
5-HT1F
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Amrutkar, D. V. et al. 2012. Pain.153, 830.
Phebus, L. A. et al. 1997. Life Sci.61, 2117.
Phebus, L. A. et al. 1997. Life Sci.61, 2117.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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