5.08228
L- Buthionine Sulfoximine
≥97% (TLC), g-glutamylcysteine synthetase inhibitor, powder
别名:
L- Buthionine Sulfoximine
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关于此项目
经验公式（希尔记法）:
C8H18N2O3S
化学文摘社编号:
分子量:
222.31
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
L- Buthionine Sulfoximine,
InChI
1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m0/s1
InChI key
KJQFBVYMGADDTQ-CVSPRKDYSA-N
assay
≥97% (TLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
water: 50 mg/mL
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Primary Target
gamma-glutamylcysteine synthetase
gamma-glutamylcysteine synthetase
Disclaimer
Toxicity: Standard Handling (A)
General description
A cell-permeable, sulfoximine based compound that acts a potent, fast acting, irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. Closely resembles the structure of g-glutamylphosphate cysteine adduct. The inhibition follows the first order kinetics with t1/2 = ~ 11 sec at saturating inhibitor concentration. Does not affect the activity of glutamine synthetase. Shown to improve the outcome of chemotherapy by lowering the levels of glutathione in cancer cells (IC50 = 1.9, 8.6, and 29 µM in melanoma, breast, and ovarian tumor cells, respectively).
Other Notes
Fruehauf, J.P., et al. 1997. Pigment Cell Res.10, 236.
OʹDwyer, P.J., et al. 1996. J. Clin. Oncol.14, 249.
Griffith, O. W., 1982. J. Biol. Chem.257, 13704.
Griffith, O. W., et al. 1979. J. Biol. Chem.254, 7558.
OʹDwyer, P.J., et al. 1996. J. Clin. Oncol.14, 249.
Griffith, O. W., 1982. J. Biol. Chem.257, 13704.
Griffith, O. W., et al. 1979. J. Biol. Chem.254, 7558.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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