5.09707
(S)-5-Iodowillardiine
别名:
(S)-5-Iodowillardiine, (S)-α-Amino-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoic acid, (S)-2-amino-3-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoic acid, Iodowillardiine
方案
≥98% (HPLC)
质量水平
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
1 M NaOH: 25 mM
储存温度
2-8°C
InChI
1S/C7H8IN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1
InChI key
AXXYLTBQIQBTES-BYPYZUCNSA-N
一般描述
A potent agonist highly selective for GluK1-containing subtype kainate receptors (EC50 = 0.06 and 0.21 µM for GluK1/K5 and GluK1, respectively) over GluK2-containing subtypes (EC50 = 0.47 and 30 µM for GluK1/K2 and GluK2/K5 respectively). Does not interact with GluK2, GluK6, and GluK7 receptors. Low affinity to AMPA receptors (EC50 = 1.5 and 33.6 µM for GluA2 and GluA1 respectively). Has been used in assessing the functional roles of GluK1-containing subtype kainate receptors in neuropathic pains, apoptosis, and necrosis.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
生化/生理作用
Primary Target
GluK1
GluK1
包装
Packaged under inert gas
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Bhangoo, K., et al. 2013. Mol. Pharmacol.83, 307.
Moldrich, X., et al. 2000. J. Neurosci. Res.59, 788.
Chittajallu, R., et al. 1999. Trends Pharmacol. Sci.20, 26.
Swanson, T., et al. 1998. Mol. Pharmacol.53, 942.
Moldrich, X., et al. 2000. J. Neurosci. Res.59, 788.
Chittajallu, R., et al. 1999. Trends Pharmacol. Sci.20, 26.
Swanson, T., et al. 1998. Mol. Pharmacol.53, 942.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°C)
Not applicable
法规信息
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