5.09708
SKF-97541
别名:
SKF-97541, GABA B Receptor Agonist, SKF-97541, SKF 97541, CGP 35024, 3-APMPA
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关于此项目
经验公式（希尔记法）:
C4H12NO2P
化学文摘社编号:
分子量:
137.12
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (TLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
assay
≥98% (TLC)
Quality Segment
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
water: 100 mM
storage temp.
2-8°C
SMILES string
[P](=O)(O)(CCC[N+H3])C
InChI
1S/C4H12NO2P/c1-8(6,7)4-2-3-5/h2-5H2,1H3,(H,6,7)/p+1
InChI key
NHVRIDDXGZPJTJ-UHFFFAOYSA-O
General description
A highly potent agonist of GABAB receptor. Depresses excitatory postsynaptic potentials mediated by glutamate in the striatum, and hyperpolarized neurones in the substantia nigra (IC50 = 92 nM). Shown to be about 10-times more potent than baclofen (Cat. No. 505873). Induces vasodepression in pulmonary vascular bed that is modulated by an ATP-sensitive K+ channel. Induces gastric acid secretion in a dose-dependent manner (0.01 - 3 mg/kg, i.v.) in mice.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Biochem/physiol Actions
Primary Target
GABAB
GABAB
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Kaye, A.D., et al. 2004. Anesth. Analg.99, 758.
Piqueras, L., and Martinez, V. 2004. Br. J. Pharmacol.142, 1038.
Seabrook, G.R., et al. 1990. Br. J. Pharmacol.101, 949.
Piqueras, L., and Martinez, V. 2004. Br. J. Pharmacol.142, 1038.
Seabrook, G.R., et al. 1990. Br. J. Pharmacol.101, 949.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable