512731
Paromomycin Sulfate
An aminoglycoside antibiotic containing 5 amino groups that exhibits antibacterial and antiamebic activity.
别名:
Paromomycin Sulfate, Neomycin E
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关于此项目
Quality Segment
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
off-white
solubility
water: soluble
shipped in
ambient
storage temp.
10-30°C
InChI
1S/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;1-5(2,3)4/h5-23,29-36H,1-4,24-28H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18?,19-,20-,21-,22-,23?;/m1./s1
InChI key
LJRDOKAZOAKLDU-UMIPPVEZSA-N
General description
An aminoglycoside antibiotic containing 5 amino groups that exhibits antibacterial and antiamebic activity. Recent NMR evidence indicates that paromomycin binding to the A-site of 16S rRNA induces a local conformational change, suggesting a mechanism for aminoglycoside action on protein translation. Also exhibits anti-protozoal properties.
Potency: ≥675 µg/mg.
Other Notes
VanLoock, M.S., et al. 1999. J. Mol. Biol. 285, 2069.
Blanchard, S.C., et al. 1998. Biochemistry 37, 7716.
Fourmy, D., et al. 1998. J. Mol. Biol. 277, 333.
Blanchard, S.C., et al. 1998. Biochemistry 37, 7716.
Fourmy, D., et al. 1998. J. Mol. Biol. 277, 333.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable