513024-M
PD 151746
A cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the calcium binding sites of calpain.
别名:
PD 151746, 3-(5-Fluoro-3-indolyl)-2-mercapto-(Z)-2-propenoic Acid
InChI
1S/C11H8FNO2S/c12-7-1-2-9-8(4-7)6(5-13-9)3-10(16)11(14)15/h1-5,13,16H,(H,14,15)/b10-3-
InChI key
HWMQHECFXSVZGN-KMKOMSMNSA-N
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
orange
solubility
DMSO: 200 mg/mL, methanol: 5 mg/mL
storage temp.
−20°C
General description
A cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the calcium binding sites of calpain. Displays over 20-fold greater selectivity for calpain-1 (Cat. Nos. 208712 and 208713) over calpain-2 (Cat. Nos. 208715 and 208718 ) (Ki values: 260 nM and 5.33 µM, respectively). Has been shown to prevent cycloheximide-induced apoptosis.
Biochem/physiol Actions
Primary Target
calpain-1
calpain-1
Target Ki: 260 nM against calpain-1
Preparation Note
Unstable in solution; reconstitute just prior to use.
Other Notes
Squier, M.K., et al. 1999. J. Cell Physiol.178, 311.
Wang, K.K., et al. 1996. Proc. Natl. Acad. Sci. USA93, 6687.
Wang, K.K., et al. 1996. Proc. Natl. Acad. Sci. USA93, 6687.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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