516090-M
Penciclovir
A carba analog of Ganciclovir. Active against several herpes viruses. Induces apoptosis effectively without exerting much genotoxicity.
别名:
Penciclovir, 2-Amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6H-purin-6-one
InChI
1S/C10H15N5O3/c11-10-13-8-7(9(18)14-10)12-5-15(8)2-1-6(3-16)4-17/h5-6,16-17H,1-4H2,(H3,11,13,14,18)
InChI key
JNTOCHDNEULJHD-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
water: 1 mg/mL, aqueous buffer, pH 2.0: 10 mg/mL
storage temp.
−20°C
Quality Level
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General description
A carba analog of Ganciclovir (Cat. No. 345700). Active against several herpes viruses (IC50 = 37.9 µM for HHV-6A and 77.8 µM for HHV-6B). Induces apoptosis effectively without exerting much genotoxicity.
A synthetic acyclic guanine derivative and a carba analog of Ganciclovir (Cat. No. 345700) that is active against several herpes viruses (IC50 = 37.9 µM for HHV-6A and 77.8 µM for HHV-6B). Induces apoptosis effectively without exerting much genotoxicity.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.
Other Notes
Leary, J.J., et al. 2002.Antimicrob. Agents Chemother.46, 762.
Amjad, M., et al. 2001. Microbiol. Immunol.45, 233.
Thust, R., et al. 2000. Cancer Gene Ther.7, 107.
Thust, R., et al. 1996. Antiviral Res.31, 105.
Shaw, T., et al. 1994. Antimicrob. Agents Chemother.38, 719.
Harnden, M.R. 1989. J. Med. Chem.32, 1738.
Amjad, M., et al. 2001. Microbiol. Immunol.45, 233.
Thust, R., et al. 2000. Cancer Gene Ther.7, 107.
Thust, R., et al. 1996. Antiviral Res.31, 105.
Shaw, T., et al. 1994. Antimicrob. Agents Chemother.38, 719.
Harnden, M.R. 1989. J. Med. Chem.32, 1738.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Carcinogenic / Teratogenic (D)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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