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Merck
CN

517301

P-Glycoprotein Inhibitor, C-4

The P-Glycoprotein Inhibitor, C-4 controls the biological activity of P-Glycoprotein. This small molecule/inhibitor is primarily used for Cancer applications.

别名:

P-Glycoprotein Inhibitor, C-4, (E)-4-Chloro-N-(3-(3-(4-hydroxy-3-methoxyphenyl)acryloyl)phenyl)benzamide, C-4

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关于此项目

经验公式（希尔记法）:
C23H18ClNO4
化学文摘社编号:
864426-22-2
分子量:
407.85
UNSPSC Code:
12352202
NACRES:
NA.77
PubChem Substance ID:
16062976

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产品名称

P-Glycoprotein Inhibitor, C-4, The P-Glycoprotein Inhibitor, C-4 controls the biological activity of P-Glycoprotein. This small molecule/inhibitor is primarily used for Cancer applications.

InChI

1S/C23H18ClNO4/c1-29-22-13-15(6-12-21(22)27)5-11-20(26)17-3-2-4-19(14-17)25-23(28)16-7-9-18(24)10-8-16/h2-14,27H,1H3,(H,25,28)

InChI key

SFYVLZRWJCFMTJ-UHFFFAOYSA-N

SMILES string

COC1=C(C=CC(=C1)C=CC(=O)C2=CC(=CC=C2)NC(=O)C3=CC=C(C=C3)Cl)O

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

相关类别

Biochem/physiol Actions

Cell permeable: yes
Primary Target
P-Glycoprotein
Product does not compete with ATP.
Reversible: yes

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable cinnamoyl compound that reversibly inhibits P-gp (P-glycoprotein) efflux function and reverses the MDR (multidrug resistance) phenotype with no noticeable effect on P-gp expression. Shown to significantly enhance Paclitaxel- (Cat. No. 580555) and Vincristine- (Cat. No. 677181) induced cytotoxicity as well as apoptosis in P-gp expressing KBV20C cells.

Other Notes

Kim, Y.K., et al. 2007. Biochem. Biophys. Res. Commun.355, 136.
Woo, H.B., et al. 2005. Bioorg. Med. Chem. Lett.15, 3782.

Packaging

Packaged under inert gas

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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