528120
PIPER - CAS 213416-70-7 - Calbiochem
A perylene-based ligand that potently inhibits human telomerase by binding to G-quadruplex DNA.
别名:
PIPER - CAS 213416-70-7 - Calbiochem, N,Nʹ- bis[2-(1-Piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic Diimide, Telomerase Inhibitor IV, N,Nʹ-bis[2-(1-Piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic Diimide, Telomerase Inhibitor IV
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
dark purple
solubility
5% acetic acid: 50 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A perylene-based ligand that potently inhibits human telomerase by binding to G-quadruplex DNA. The strongest binding site for PIPER appears to be the 3′-boundary of the G-quadruplex. Can also bind non-specifically to nucleic acids. May also be useful as an antiproliferative agent.
A perylene-based ligand that potently inhibits human telomerase by binding to G-quadruplex DNA. The strongest binding site for PIPER appears to be the 3′-boundary of the G-quadruplex. Can also bind non-specifically to nucleic acids. May be useful as an antiproliferative agent.
Biochem/physiol Actions
Cell permeable: no
Primary Target
human telomerase
human telomerase
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Other Notes
Han, H., et al. 1999. Biochemistry38, 6981.
Fedoroff, O.Y., et al. 1998. Biochemistry 37, 12367.
Fedoroff, O.Y., et al. 1998. Biochemistry 37, 12367.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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