528822
PARP Inhibitor XII
The PARP Inhibitor XII, also referenced under CAS 489457-67-2, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.
别名:
PARP Inhibitor XII, 3-(4-Chlorophenyl)quinoxaline-5-carboxamide
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About This Item
经验公式（希尔记法）:
C15H10ClN3O
CAS Number:
分子量:
283.71
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
light brown
溶解性
DMSO: 10 mg/mL
运输
ambient
储存温度
2-8°C
SMILES字符串
Clc1ccc(cc1)c2nc3c(nc2)cccc3C(=O)N
InChI
1S/C15H10ClN3O/c16-10-6-4-9(5-7-10)13-8-18-12-3-1-2-11(15(17)20)14(12)19-13/h1-8H,(H2,17,20)
InChI key
FLYGLPYJEQPCFY-UHFFFAOYSA-N
一般描述
A potent quinoxaline-based PARP inhibitor with a ~5-fold selectivity towards PARP-2 over PARP-1 (IC50 = 7 and 33 nM, respectively). Reported to be brain-permeant and exhibit good pharmacokinetics.
包装
Packaged under inert gas
其他说明
Ishida, J., et al. 2006. Bioorg. Med. Chem.14, 1378.
Iwashita, A., et al. 2005. FEBS Lett.579, 1389.
Iwashita, A., et al. 2005. FEBS Lett.579, 1389.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Irritant (B)
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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