General description
A negative control for the Src family protein tyrosine kinase inhibitor PP2. However, it inhibits the activity of EGFR kinase (IC50 = 2.7 μM).
Application
PP3 is a negative control for the Src family protein tyrosine kinase inhibitor PP2 (Cat. No. 529573). However, it inhibits the activity of EGFR kinase (IC50 = 2.7 μM).
Biochem/physiol Actions
Target IC50:2.7 μM against EGFR kinase
Preparation Note
Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
Further dilute with aqueous buffers just prior to use
存储类别
11 - Combustible Solids
wgk
WGK 1
法规信息
监管及禁止进口产品
此项目有
P Traxler et al.
Journal of medicinal chemistry, 40(22), 3601-3616 (1997-11-14)
In the course of the random screening of a pool of CIBA chemicals, the two pyrazolopyrimidines 1 and 2 have been identified as fairly potent inhibitors of the EGF-R tyrosine kinase. Using a pharmacophore model for ATP-competitive inhibitors interacting with
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