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Merck
CN

529574

PP3 - CAS 5334-30-5 - Calbiochem

别名:

4-Amino-7-phenylpyrazol[3,4-d]pyrimidine

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UNSPSC Code:
12352200
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assay

≥95% (HPLC)

Quality Level

form

solid

color

off-white

solubility

DMSO: soluble

General description

A negative control for the Src family protein tyrosine kinase inhibitor PP2. However, it inhibits the activity of EGFR kinase (IC50 = 2.7 μM).

Application

PP3 is a negative control for the Src family protein tyrosine kinase inhibitor PP2 (Cat. No. 529573). However, it inhibits the activity of EGFR kinase (IC50 = 2.7 μM).

Biochem/physiol Actions

Target IC50:2.7 μM against EGFR kinase

Preparation Note

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
Further dilute with aqueous buffers just prior to use


存储类别

11 - Combustible Solids

wgk

WGK 1

法规信息

监管及禁止进口产品

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相关内容


P Traxler et al.
Journal of medicinal chemistry, 40(22), 3601-3616 (1997-11-14)
In the course of the random screening of a pool of CIBA chemicals, the two pyrazolopyrimidines 1 and 2 have been identified as fairly potent inhibitors of the EGF-R tyrosine kinase. Using a pharmacophore model for ATP-competitive inhibitors interacting with