InChI key
XSHQBIXMLULFEV-UHFFFAOYSA-N
InChI
1S/C19H19N5/c1-19(2,3)24-18-15(17(20)21-11-22-18)16(23-24)14-10-6-8-12-7-4-5-9-13(12)14/h4-11H,1-3H3,(H2,20,21,22)
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
off-white
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
主要靶标
I338G突变体v-Src
I338G突变体v-Src
产物与ATP竞争。
可逆性：是
细胞可渗透性：具有
靶标IC50：I338G突变体v-Src为1.5 nM；野生型v-Src为1.0 µM；野生型Fyn为600 nM
Disclaimer
毒性：标准处理（A）
General description
Src家族酪氨酸激酶的强效，可逆，ATP竞争性和细胞可渗透抑制剂，与野生型v-Src（IC50=1.0 µnM）相比，对I338G突变体v-Src（IC50 = 1.5 nM）的选择性高>800倍。也抑制野生型Fyn（IC50=600 nM）。 也有InSolution 格式（目录号529605）。
Src家族酪氨酸激酶的强效，可逆，ATP竞争性，细胞可渗透和选择性抑制剂，与野生型v-Src（IC50 = 1 µM）相比，对I338G突变体v-Src（IC50 = 1.5 nM）的选择性高>800倍。也抑制野生型Fyn（IC50=600 nM）。 也有InSolution 格式（目录号529605）。
Legal Information
不可在美国销售。
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Bishop, A.C., et al. 2000.Nature407, 395.
Bishop, A.C., et al. 1999 J. Am. Chem. Soc.121, 627.
Bishop, A.C., et al. 1999 J. Am. Chem. Soc.121, 627.
Packaging
用惰性气体包装
Preparation Note
在复溶后存放于冰箱（4°C）。储备溶液在4°C下可稳定保存3个月。
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Nicolas Loyer et al.
eLife, 13 (2024-06-13)
The generation of distinct cell fates during development depends on asymmetric cell division of progenitor cells. In the central and peripheral nervous system of Drosophila, progenitor cells respectively called neuroblasts or sensory organ precursors use PAR polarity during mitosis to
KangBo Ng et al.
Current biology : CB, 33(20), 4298-4311 (2023-09-21)
During development, the conserved PAR polarity network is continuously redeployed, requiring that it adapt to changing cellular contexts and environmental cues. In the early C. elegans embryo, polarity shifts from being a cell-autonomous process in the zygote to one that must
KangBo Ng et al.
microPublication biology, 2022 (2022-08-24)
Engineered analog sensitive kinases provide a highly effective method for acute, controllable, and highly selective inhibition of kinase activity. Here we describe the design and characterization of an analog sensitive allele of the polarity kinase, PKC-3. This allele supports normal
Mai Usui et al.
Genes to cells : devoted to molecular & cellular mechanisms, 21(4), 302-310 (2016-01-27)
Brown adipocytes and beige adipocytes can expend energy, generate heat, and increase whole-body energy expenditure. The detailed mechanisms of adipogenesis and thermogenesis of these cells are still obscure. Here, we show that Src family kinases (SFKs) regulate both brown adipogenesis
Venkatesh Kundumani-Sridharan et al.
Arteriosclerosis, thrombosis, and vascular biology, 41(8), 2293-2314 (2021-05-28)
[Figure: see text].
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