Mnk2 Inhibitor IV

A cell permeable phenylaminopyrimidine derived compound that acts as a selective inhibitor of mitogen-activated protein kinase-interacting kinase 2 (Mnk2, K_i = 370 nM. Displays high selectivity over CDK2 (K_i >10 µM) and CDK9 (K_i = 1.66 µM). Shown to block the phosphorylation of elF4E in and effectively inhibit the proliferation of MV4-11 cells (GI₅₀ = 780 nM) by inducing a cell cycle arrest at G0/G1 phase. Diminishes the expression of Mcl-1 and causes PARP cleavage in A2780 ovarian cancer cells.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Cell permeable: yes

Primary Target
Mnk2

Reversible: yes

Packaged under inert gas

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Diab, S., et al. 2014. ChemMedChem.9, 962.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Standard Handling (A)