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Merck
CN

5.31619

2-Aminopurine

别名:

2-Aminopurine, 2-AP, 2AP

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关于此项目

经验公式（希尔记法）:
C5H5N5
化学文摘社编号:
452-06-2
分子量:
135.13
UNSPSC Code:
12352200
MDL number:
MFCD00005566
Assay:
≥97% (HPLC)
Form:
powder
Solubility:
DMSO: 50 mg/mL

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InChI

1S/C5H5N5/c6-5-7-1-3-4(10-5)9-2-8-3/h1-2H,(H3,6,7,8,9,10)

InChI key

MWBWWFOAEOYUST-UHFFFAOYSA-N

assay

≥97% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 50 mg/mL

fluorescence

λex 303 nm, λem 370 nm

Quality Level

200

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General description

A cell permeable adenine analog that is widely used as a versatile fluorescent probe to investigate RNA and DNA secondary and tertiary structures and their conformation dynamics in response to local environment when interacting with other biomolecules with great sensitivity. Forms stable base pairs with neucleobase uracil found in RNA and thymine in DNA, and moderately stable base pairs with cytosine. Exhibits intensive fluorescence emission (lAbsmax = 303 nM, lflmax = 370 nM, and fluorescence quantum yield in solution QFI = 0.68) and longer excitation wavelength compared with other neucleobases enabling its selective excitation with low background signals.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
DNA and RNA
Reversible: yes

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Ma, L., et al. 2014. Biochem. Biophys. Res. Comm.449, 120.
Widom, J. R., et al. 2013. New. J. Phys.15, 025028.
Souliere, M. F., et al. 2011. J. Am. Chem. Soc.133, 16161,
Jean, J. M., et al. 2001. PNAS98,37.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Long Ma et al.
Biochemical and biophysical research communications, 449(1), 120-125 (2014-05-13)
EcoP15I is a Type III DNA restriction and modification enzyme of Escherichia coli. We show that it contains two modification (Mod) subunits for sequence-specific methylation of DNA and one copy of a restriction endonuclease (Res) subunit for cleavage of DNA
J M Jean et al.
Proceedings of the National Academy of Sciences of the United States of America, 98(1), 37-41 (2000-12-20)
2-Aminopurine (2AP) is a fluorescent analog of guanosine and adenosine and has been used to probe nucleic acid structure and dynamics. Its spectral features in nucleic acids have been interpreted phenomenologically, in the absence of a rigorous electronic description of
Marie F Soulière et al.
Journal of the American Chemical Society, 133(40), 16161-16167 (2011-09-03)
A precise tertiary structure must be adopted to allow the function of many RNAs in cells. Accordingly, increasing resources have been devoted to the elucidation of RNA structures and the folding of RNAs. 2-Aminopurine (2AP), a fluorescent nucleobase analogue, can
Julia R Widom et al.
New journal of physics, 15 (2013-11-14)
We have observed the conformation-dependent electronic coupling between the monomeric subunits of a dinucleotide of 2-aminopurine (2-AP), a fluorescent analog of the nucleic acid base adenine. This was accomplished by extending two-dimensional fluorescence spectroscopy (2D FS) - a fluorescence-detected variation

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