方案
≥99% (TLC and GC)
质量水平
表单
crystalline solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
water: 5 mg/mL
储存温度
−20°C
InChI
1S/C20H32O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22;/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22);/q;+1/p-1/b7-6-,10-9-,13-12-,16-15-;
InChI key
DDMGAAYEUNWXSI-XVSDJDOKSA-M
一般描述
A cis-polyunsaturated fatty acid found in the plasma membrane. Major component of membrane phospholipids. Following its release by cellular phospholipases, it is enzymatically converted to a variety of inflammatory and vasoactive metabolites, such as prostaglandins (via the cyclooxygenase pathway), leukotrienes (via the lipoxygenase pathway), and epoxides (via the cytochrome P450 pathway). Binds to G-protein α-subunits in a covalent, posttranslational manner. Inhibits Ras-GAP. Stimulates the synthesis of nitric oxide by platelets.
Precursor for prostaglandins, prostacyclin, and thromboxane. Binds to G-protein α-subunits in a covalent, post-translational manner. Inhibits Ras-GAP. Stimulates the synthesis of nitric oxide by platelets. Modulates nitric oxide production by prostaglandin synthesis via the cyclooxygenase pathway.
生化/生理作用
Cell permeable: no
Primary Target
Ras-GAP
Ras-GAP
Product does not compete with ATP.
Reversible: no
包装
Packaged under inert gas
警告
Toxicity: Harmful (C)
重悬
Unstable in solution; reconstitute just prior to use.
其他说明
Hallak, H., et al. 1994. J. Biol. Chem.269, 4713.
Khurana, G., and Bennett, M.R. 1993. Br. J. Pharmacol.109, 480.
Han, J.-W., et al. 1991. Science252, 576.
Radomski, M.W., et al. 1990. Br. J. Pharmacol.101, 325.
Neddleman, P., et al. 1986. Annu. Rev. Biochem.55, 69.
Khurana, G., and Bennett, M.R. 1993. Br. J. Pharmacol.109, 480.
Han, J.-W., et al. 1991. Science252, 576.
Radomski, M.W., et al. 1990. Br. J. Pharmacol.101, 325.
Neddleman, P., et al. 1986. Annu. Rev. Biochem.55, 69.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
235.4 °F - closed cup
闪点(°C)
113 °C - closed cup
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