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Merck
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About This Item

经验公式(希尔记法):
C20H31O2 · Na
CAS Number:
分子量:
326.45
MDL编号:
UNSPSC代码:
12352200
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方案

≥99% (TLC and GC)

质量水平

表单

crystalline solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

white

溶解性

water: 5 mg/mL

储存温度

−20°C

InChI

1S/C20H32O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22;/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22);/q;+1/p-1/b7-6-,10-9-,13-12-,16-15-;

InChI key

DDMGAAYEUNWXSI-XVSDJDOKSA-M

一般描述

A cis-polyunsaturated fatty acid found in the plasma membrane. Major component of membrane phospholipids. Following its release by cellular phospholipases, it is enzymatically converted to a variety of inflammatory and vasoactive metabolites, such as prostaglandins (via the cyclooxygenase pathway), leukotrienes (via the lipoxygenase pathway), and epoxides (via the cytochrome P450 pathway). Binds to G-protein α-subunits in a covalent, posttranslational manner. Inhibits Ras-GAP. Stimulates the synthesis of nitric oxide by platelets.
Precursor for prostaglandins, prostacyclin, and thromboxane. Binds to G-protein α-subunits in a covalent, post-translational manner. Inhibits Ras-GAP. Stimulates the synthesis of nitric oxide by platelets. Modulates nitric oxide production by prostaglandin synthesis via the cyclooxygenase pathway.

生化/生理作用

Cell permeable: no
Primary Target
Ras-GAP
Product does not compete with ATP.
Reversible: no

包装

Packaged under inert gas

警告

Toxicity: Harmful (C)

重悬

Unstable in solution; reconstitute just prior to use.

其他说明

Hallak, H., et al. 1994. J. Biol. Chem.269, 4713.
Khurana, G., and Bennett, M.R. 1993. Br. J. Pharmacol.109, 480.
Han, J.-W., et al. 1991. Science252, 576.
Radomski, M.W., et al. 1990. Br. J. Pharmacol.101, 325.
Neddleman, P., et al. 1986. Annu. Rev. Biochem.55, 69.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

235.4 °F - closed cup

闪点(°C)

113 °C - closed cup


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