5.33574
TRPML3 Activator, ML123
别名:
TRPML3 Activator, ML123, 4-Chloro-N-(2-morpholinocyclohexyl)benzenesulfonamide, SF-21, CID2911646, ML123, ML 123, Transient Receptor Potential Channel 3 Activator, SID24801657, Racemate, SR-1984
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关于此项目
经验公式（希尔记法）:
C16H23ClN2O3S
化学文摘社编号:
分子量:
358.88
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
Assay:
≥92% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
assay
≥92% (HPLC)
Quality Segment
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 50 mg/mL
storage temp.
2-8°C
SMILES string
C1CCC(C(C1)NS(=O)(=O)C2=CC=C(C=C2)Cl)N3CCOCC3
InChI key
AYQCZQKMGKDZPS-UHFFFAOYSA-N
General description
A non-cytotoxic morpholinyl-cyclohexylbenzenesulfonamide compound that acts as a selective agonist of TRPML3 channel (EC50 = 873 nM in hTRPML3-YPF transfected HEK293 cells). Displays significantly weaker agonistic activity for TRPML2 channel (54.5% at 10 µM) and is shown to be inactive against hTRPML1, hTRPM2, mTRPV2, hTRPC3, drTRPN1, and hTRPA1 (~10 µM). Also binds to sigma-1 receptor at much higher concentrations (IC50 = 31 µM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
TRPML3
TRPML3
Reversible: yes
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Antolin, A.A., and Mestres, J. 2015. ACS Chem. Biol.10, 395.
Grimm, C., et al. 2012. J. Biol. Chem.287, 22701.
Saldanha, S., et al. 2010. Probe Reports from the NIH Molecular Libraries Program.
Grimm, C., et al. 2010. Chem. Biol.17, 135.
Grimm, C., et al. 2012. J. Biol. Chem.287, 22701.
Saldanha, S., et al. 2010. Probe Reports from the NIH Molecular Libraries Program.
Grimm, C., et al. 2010. Chem. Biol.17, 135.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
警示词
Warning
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
存储类别
11 - Combustible Solids
怎么回事？
WGK 3
闪点 (F)
Not applicable
闪点 (°C)
Not applicable