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Merck
CN
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About This Item

经验公式(希尔记法):
C34H47BF2N4O2
分子量:
592.57
UNSPSC代码:
12352202
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方案

≥98% (HPLC)

质量水平

表单

powder

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

dark purple

荧光

λex 570 nm
λem 585 nm

储存温度

−20°C

一般描述

A cell-permeable, photostable, bodipy-derived fluorescent probe that can be used for real-time imaging of lysosomal dynamics in proliferating cells undergoing mitosis. Undergoes rapid re-localization from cytoplasm to nucleus during cell division, but does not interfere with cell cycle. Displays a sharp increase in intensity during mitosis and its fluorescence displays high sensitivity to acidic environment (pH 2-4). Can also be used for time-dependent whole-body in vivo imaging of tumor xenografts (CDy6 stained HeLa cells, s.c.) in BALB/c nude mice up to 21 days. Exhibits greater brightness, higher photostability, and significantly reduced toxicity when compared to LysoTracker Red, LysoTracker Green, LysoSensor Green and HOE33342. Abs max: 570 nm; Em max: 585 with a quantum yield of 0.89.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

生化/生理作用

Cell permeable: yes
Primary Target
cytoplasm
Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C). Store in a dark vial, protected from light.
Use only fresh, anhydrous DMSO for reconstitution.

其他说明

Jeong, Y.M., et al. 2015. Chem. Biol.22, 299.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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