5.34034
Heterochromatin Inhibitor, HMS-I1
别名:
Heterochromatin Inhibitor, HMS-I1, 2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-6-methylimidazo[1,2-a]pyridine, 2-(2,3-Dihydro-1,4-benzo[b][1,4]dioxin-6-yl)-6-methylimidazo[1,2-a]pyridine, Heterochromatin Mediated Silencing Inhibitor 1
方案
≥98% (HPLC)
质量水平
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
pale yellow
溶解性
DMSO: 50 mg/mL
储存温度
2-8°C
SMILES字符串
CC1=CN2C=C(N=C2C=C1)C3=CC4=C(C=C3)OCCO4
一般描述
A cell-permeable imidazopyridine based compound that lacks canonical zinc chelating moieties and acts in a reversible manner to disrupt heterochromatin-mediated transcriptional gene silencing in mammalian, fungal, and plant cells (5 - 10 µM). Targets Clr3-containing Snf2/HDAC repressor complex (SHREC) and inhibits HDAC6 and HDAC10 activities. Increases G418 resistance of cen1-kanMX cells. Shown to diminish H3K9 methylation and increase H3K9 and H3K14 acetylation in cells grown in the presence of G418. Murine erythroleukemia (MEL) cells grown in the presence of this compound can overcome α-satellite repeats-mediated gene silencing.
生化/生理作用
Cell permeable: yes
Primary Target
Clr3-containing Snf2/HDAC repressor complex (SHREC)
Clr3-containing Snf2/HDAC repressor complex (SHREC)
Reversible: yes
包装
Packaged under inert gas
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Castonguay, E., et al. 2015. Mol. Cell. Biol.35, 662.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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