hCNT2 Inhibitor

An aminoadenosine derivative that acts as a potent human concentrative nucleoside transporter 2 inhibitor. Dose-dependently blocks Na⁺-dependent inosine uptake in COS-7 cells transiently expressing hCNT2 with an IC₅₀ of 0.64 µM. The anti conformer is suggested to be more bioactive than syn.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Primary Target
hCNT2

Reversible: yes

Target IC₅₀: 640 nM in COS-7 cells

Packaged under inert gas

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Tatani, K., et al. 2015. ACS Med. Chem. Lett.6, 244.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Standard Handling (A)