A cell-permeable, bioavailable, indoline derivative that acts as a highly potent inhibitor of acyl CoA:monoacylglycerol acyltransferase 2 inhibitor (MGAT2, IC₅₀ = 3.4 nM). Displays good microsomal stability and desirable pharmacokinetic properties (F = 52%; AUC 0 - 8 h = 842 ng/h/ml). Effectively suppresses the elevation of plasma triacylglyceride levels after olive oil challenge in C57BL/6J mice (10 - 30 mg/kg; p.o.).

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Cell permeable: yes

Primary Target
MGAT2

Reversible: yes

Target IC₅₀: 3.4 nM for MGAT inhibition

Packaged under inert gas

Toxicity: Standard Handling (A)

Sato, K., et al. 2015. J. Med. Chem.58, 3892.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany