539212
HMTase Inhibitor III, BIX-01338
The Protein Methyltransferase Inhibitor II, BIX-01338 controls the biological activity of Protein Methyltransferase. This small molecule/inhibitor is primarily used for Cell Structure applications.
别名:
HMTase Inhibitor III, BIX-01338, EHMT1/GLP Inhibitor I, EHMT2/G9a Inhibitor III, 1-(4-(4-methoxybenzoyloxy)phenethyl)-2-(4-(trifluoromethyl)benzamido)-1H-benzo[d]imidazole-5-carboxylic acid, Hydrate, 1-(2-(4-(4-Methoxybenzoyloxy)phenyl)ethyl)-2-(4-trifluoromethylbenzoylamino)-1H-benzoim
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关于此项目
经验公式（希尔记法）:
C32H24F3N3O6 · xH2O
分子量:
603.54 (anhydrous basis)
UNSPSC Code:
12352200
SMILES string
O=C(C1=CC=C(C=C1)C(F)(F)F)NC2=NC3=C(N2CCC4=CC=C(OC(C5=CC=C(C=C5)OC)=O)C=C4)C=CC(C(O)=O)=C3.[xH2O]
assay
≥97% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
off-white
solubility
DMSO: 100 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
A cell-permable amino-benzimidazolo compound that inhibits a broad-spectrum of histone methyltransferases, including PRMT1, SET7/9, G9a, SUV39H1, and GLP (effective conc. = 15 µM) in a SAM-competitive manner. BIX-01338 is reported to affect the growth of mES, MEF, and HeLa cells at concentrations needed for HMT inhibition, limiting its use in HMTase studies to cell-free systems only.
A cell-permeable amino-benzimidazolo compound that is shown to inhibit a broad-spectrum of histone methyltransferases, including the PRMT1 H4R3 me2 activity, SET7/9 H3K4 me activity, G9a H3K9 me2 activity, as well as the H3K9 me3 activity of SUV39H1 (wild-type and H320R hyperactive mutant) and GLP (effective conc. = 15 µM) in a SAM-competitive manner. BIX-01338 is reported to affect the growth of mES, MEF, and HeLa cells at 13.3 µM, while failing to affect cellular H3K9me/me2/me3 and H3K27me2 levels at a lower non-cytotoxic concentration of 3.3 µM, limiting its use in HMTase studies to cell-free systems only.
Packaging
Packaged under inert gas
Preparation Note
Following initial thaw, aliquot and freeze (-20°C).
Other Notes
Kubicek, S., et al. 2007. Mol. Cell25, 473.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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