Recombinant, human PP2Cα fused to a His•Tag sequence and expressed in E. coli. A Mn²⁺- or Mg²⁺-dependent protein serine/threonine phosphatase that is essential for regulating cellular stress response, gene expression and replication in eukaryotes. Recently it has been shown that PP2Cα inhibits cell growth and activates the p53 pathway.

Please refer to vial label for lot-specific concentration.

In PBS, pH 7.4.

Following initial thaw, aliquot and freeze (-70°C).

Ofek, P., et al. 2003. J. Biol. Chem.278, 14299.
Das, A.K., et al. 1996. EMBO J.15, 6798.

One unit is defined as the amount of enzyme that will hydrolyze 1.0 nmol of pNPP per min at 37°C, pH 7.4 using 10 mM of substrate.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

HIS TAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Standard Handling (A)