Raf1 Kinase Inhibitor I

A potent cRaf1 kinase inhibitor (IC₅₀ = 9 nM). Shows ~100-fold selectivity for Raf kinase versus Cdk1, Cdk2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fms. cRaf1 inhibitors are predicted to be broad spectrum anti-tumor agents.

Cell permeable: yes

Primary Target
CRAFI kinase

Product competes with ATP.

Reversible: yes

Target IC₅₀: 9 nM against cRAF1 kinase

Packaged under inert gas

Toxicity: Irritant (B)

A 10 mM (500 µg/96 µl) solution of Raf1 Inhibitor I (Cat. No. 553008) in DMSO.

Following initial use, aliquot and refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany