553003
Raf1 Kinase Inhibitor I
InSolution, ≥97%
别名:
InSolution Raf1 Kinase Inhibitor I
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关于此项目
经验公式（希尔记法）:
C15H8Br2INO2
分子量:
520.94
UNSPSC Code:
12352200
Assay:
≥97% (HPLC)
Form:
liquid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
assay
≥97% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
clear orange
shipped in
wet ice
storage temp.
2-8°C
Quality Level
General description
A potent cRaf1 kinase inhibitor (IC50 = 9 nM). Shows ~100-fold selectivity for Raf kinase versus Cdk1, Cdk2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fms. cRaf1 inhibitors are predicted to be broad spectrum anti-tumor agents.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
CRAFI kinase
CRAFI kinase
Product competes with ATP.
Reversible: yes
Target IC50: 9 nM against cRAF1 kinase
Packaging
Packaged under inert gas
Physical form
A 10 mM (500 µg/96 µl) solution of Raf1 Inhibitor I (Cat. No. 553008) in DMSO.
Preparation Note
Following initial use, aliquot and refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
188.6 °F - closed cup - (Dimethylsulfoxide)
flash_point_c
87 °C - closed cup - (Dimethylsulfoxide)
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