553212-M
雷帕霉素，乙醇溶液
InSolution, ≥98%, controls the biological activity of mTOR
别名:
InSolution雷帕霉素，乙醇溶液
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选择尺寸
关于此项目
经验公式（希尔记法）:
C51H79NO13
分子量:
914.17
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
liquid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
assay
≥98% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
storage temp.
−70°C
General description
选择性抑制p70 S6激酶的磷酸化和激活（50=0.05 nM）。防止 IGF-II 的翻译激活。还防止静止的T细胞进入细胞周期，但不直接阻止细胞周期进程。研究表明，可抑制随后的信号传导事件，例如p110Rb 磷酸化、p34cdc2激酶激活和细胞周期蛋白A合成。表现出与FK-50 6结合蛋白的强结合力。还据报道在鼠B细胞系中诱导凋亡，抑制淋巴因子诱导的细胞增殖（在G1期），并不可逆地阻滞酿酒酵母细胞（在G1期）。
Physical form
10 mM (1 mg/109 µl)雷帕霉素（目录号 553210）在EtOH中的溶液。
Preparation Note
初次解冻后，分装冻存（-70°C）。
Other Notes
Powell, D.J., et al. 2003.Mol. cell Biol.23, 7794.
Braun, W., et al. 1995.FASEB J.9, 63.
Nielsen, F.C., et al. 1995.Nature 377, 358.
Aagaard-Tillery, K.M. and Jelinek, D.F.1994.Cell.Immunol. 156, 493.
Gottschalk, A.R., et al. 1994.Proc.Natl.Acad.Sci. USA91, 7350.
Morice, W.G., et al. 1993.J. Biol. Chem.268, 3734.
Terada, N., et al. 1993.J. Biol. Chem.268, 12062.
Kuo, J., et al. 1992.Nature 358, 70.
Price, D.J., et al. 1992.Science257, 973.
Heitman, J., et al. 1991.Science253, 905.
Kay, J.E., et al. 1991.Immunology72, 544.
Schreiber, S.L.1991.Science251, 283.
Bierer, B.E., et al. 1990.Proc.Natl.Acad.Sci. USA87, 9231.
Dumont, F.J., et al. 1990.J. Immunol.144, 251.
Braun, W., et al. 1995.FASEB J.9, 63.
Nielsen, F.C., et al. 1995.Nature 377, 358.
Aagaard-Tillery, K.M. and Jelinek, D.F.1994.Cell.Immunol. 156, 493.
Gottschalk, A.R., et al. 1994.Proc.Natl.Acad.Sci. USA91, 7350.
Morice, W.G., et al. 1993.J. Biol. Chem.268, 3734.
Terada, N., et al. 1993.J. Biol. Chem.268, 12062.
Kuo, J., et al. 1992.Nature 358, 70.
Price, D.J., et al. 1992.Science257, 973.
Heitman, J., et al. 1991.Science253, 905.
Kay, J.E., et al. 1991.Immunology72, 544.
Schreiber, S.L.1991.Science251, 283.
Bierer, B.E., et al. 1990.Proc.Natl.Acad.Sci. USA87, 9231.
Dumont, F.J., et al. 1990.J. Immunol.144, 251.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：易燃（J）
signalword
Danger
hcodes
Hazard Classifications
Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2
存储类别
3 - Flammable liquids
wgk
WGK 1
flash_point_f
53.6 °F - closed cup - Information refers to the main component.
flash_point_c
12 °C - closed cup - Information refers to the main component.
法规信息
危险化学品
农药列管产品
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