553502
NSC23766 trihydrochloride
≥93% (HPLC), lyophilized, Rac1 inhibitor, Calbiochem®
别名:
Rac1抑制剂, NSC23766
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C24H38Cl3N7
化学文摘社编号:
分子量:
530.96
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
产品名称
Rac1抑制剂, Rac1 Inhibitor, CAS 1177865-17-6, is a cell-permeable, reversible inhibitor of Rac1 GDP/GTP exchange. Interferes with the interaction between Rac1 and Rac-specific GEFs Trio and Tiam1 (IC50 ~50 µM).
SMILES string
Cl.Cl.Cl.N(CCCC(Nc1nc(cc(n1)C)Nc2cc3c(nc(cc3N)C)cc2)C)(CC)CC
InChI
1S/C24H35N7.3ClH/c1-6-31(7-2)12-8-9-16(3)27-24-28-18(5)14-23(30-24)29-19-10-11-22-20(15-19)21(25)13-17(4)26-22;;;/h10-11,13-16H,6-9,12H2,1-5H3,(H2,25,26)(H2,27,28,29,30);3*1H
InChI key
CPUHORIUXPQCHW-UHFFFAOYSA-N
assay
≥93% (HPLC)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
solubility
water: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
主要靶标
Rac1
Rac1
产物不与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：针对Rac1 GDP/GTP交换活性约为50µM；针对TRAP诱导和胶原蛋白刺激的血小板聚集为50 mM和64 mM
Disclaimer
毒性：致癌/致畸（D）
General description
一种细胞渗透性嘧啶化合物，通过干扰Rac1和Rac特异性GEF（鸟嘌呤核苷酸交换因子）Trio和Tiam1（IC50 ~50 µM）之间的相互作用，特异性和可逆地抑制Rac1 GDP/GTP交换活性。显示有效抑制NIH3T3和PC-3细胞中Rac1介导的细胞功能（有效剂量~50至100 μM）。对Cdc42或RhoA激活无影响，且不影响Rac1与BcrGAP或PAK1的相互作用。减少TRAP诱导和胶原刺激的血小板聚集（IC50分别为50 mM和64 mM）。
Other Notes
Dwivedi, S., et al. 2010.J. Translational Med.8, 128.
Desire, L., et al. 2005.J. Biol. Chem.280, 37516.
Gao, Y., et al. 2004.Proc.Natl.Acad.Sci. USA101, 7618.
Desire, L., et al. 2005.J. Biol. Chem.280, 37516.
Gao, Y., et al. 2004.Proc.Natl.Acad.Sci. USA101, 7618.
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Kimia Ghaffari et al.
PLoS genetics, 17(3), e1009402-e1009402 (2021-03-20)
Impaired formation of the intrahepatic biliary network leads to cholestatic liver diseases, which are frequently associated with autoimmune disorders. Using a chemical mutagenesis strategy in zebrafish combined with computational network analysis, we screened for novel genes involved in intrahepatic biliary
Audrey Miller Williams et al.
eLife, 11 (2022-09-27)
For a group of cells to migrate together, each cell must couple the polarity of its migratory machinery with that of the other cells in the cohort. Although collective cell migrations are common in animal development, little is known about
SLIT2/ROBO1 signaling suppresses mTORC1 for organelle control and bacterial killing.
Bhosle, et al.
Life science alliance, 6 (2023)
Kee-Beom Kim et al.
Cancer research, 82(22), 4219-4233 (2022-09-15)
WNT signaling represents an attractive target for cancer therapy due to its widespread oncogenic role. However, the molecular players involved in WNT signaling and the impact of their perturbation remain unknown for numerous recalcitrant cancers. Here, we characterize WNT pathway
Shruthi Sriramkumar et al.
PloS one, 17(8), e0271584-e0271584 (2022-08-04)
Ovarian cancer (OC) is a lethal gynecological malignancy with a five-year survival rate of only 46%. Development of resistance to platinum-based chemotherapy is a common cause of high mortality rates among OC patients. Tumor and transcriptomic heterogeneity are drivers of
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持