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Merck
CN
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About This Item

线性分子式:
C24H35N7.3HCl
UNSPSC代码:
12352200
NACRES:
NA.28
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表单

liquid

质量水平

储存条件

OK to freeze

储存温度

−20°C

一般描述

A cell-permeable pyrimidine compound that specifically inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC50 ~ 50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 µM). Also shown to effectively inhibit Rac1 and Rac2 activation in Lin- c-kit+ bone marrow cells stimulated with SDF-1α (effective intraperitoneal dose of 1mg/kg). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1.

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 2


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