555556
Rho Kinase Inhibitor VII
The Rho Kinase Inhibitor VII controls the biological activity of Rho Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
Rho Kinase Inhibitor VII, ROCK Inhibitor VII, Rho Kinase Inhibitor VII
质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
颜色
light beige
溶解性
DMSO: 1 mg/mL
water: 1 mg/mL
运输
ambient
储存温度
−20°C
一般描述
A cell-permeable triaminotriazine ROCK inhibitor (IC50 = 6 nM in a cell-free ROCK1 kinase assay) that affects 24 other commonly studied non-ROCK kinases only at much higher concentrations (IC50 >2 µM) and effectively blocks MCP-1-induced THP-1 cell migration (IC50 = 30 nM) in vitro. Subcutaneous injection (3-10 mg/kg) of ROCK Inhibitor VII and oral dosing (30 mg/kg) of Y-27632 (Cat. Nos. 688000 & 688001) are both reported to significantly reduce arterial blood pressure in a spontaneous hypertensive rat model in vivo.
包装
Packaged under inert gas
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Ho, K.K., et al. 2009. Bioorg. Med. Chem. Lett.19, 6027.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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