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Merck
CN

559307

Sangivamycin - CAS 18417-89-5 - Calbiochem

别名:

Sangivamycin - CAS 18417-89-5 - Calbiochem, 7-Deaza-7-carbamoyladenosine, NSC-65346

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关于此项目

经验公式（希尔记法）:
C12H15N5O5
化学文摘社编号:
18417-89-5
分子量:
309.28
UNSPSC Code:
12352200
MDL number:
MFCD00214391

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InChI

1S/C12H15N5O5/c13-9-6-4(10(14)21)1-17(11(6)16-3-15-9)12-8(20)7(19)5(2-18)22-12/h1,3,5,7-8,12,18-20H,2H2,(H2,14,21)(H2,13,15,16)

InChI key

OBZJZDHRXBKKTJ-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

0.1 M KOH: 5 mg/mL

shipped in

ambient

Quality Level

100

General description

This product has been discontinued.



A cytotoxic purine nucleoside active against human cytomegalovirus (HCMV). A cell-permeable, reversible, selective, and potent protein kinase C (PKC) inhibitor (IC50 = 10 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to histone and lipid cofactors.

A cytotoxic purine nucleoside active against human cytomegalovirus (HCMV). A cell-permeable, reversible, selective, and potent protein kinase C (PKC) inhibitor (IC50 = 10 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to histone and lipid cofactors.

Biochem/physiol Actions

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Target IC50: 10 µM against PKC

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Greene, N.M., et al. 1995. J. Biol. Chem. 270, 6710.
Osada, H., et al. 1989. J. Antibiot. 42, 402.
Loomis, C.R. and Bell, R.M. 1988. J. Biol. Chem. 263, 1682.
Turk, S.R., et al. 1987. Antimicrob. Agents Chemother. 31, 544.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Highly Toxic (H)

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

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