一般描述
A cell permeable, reversible, and ATP-competitive sulfone metabolite of the p38 MAP kinase inhibitor, SB 203580 (Cat. No. 559389). Potently inhibits p38 MAP kinase (IC50 = 30 nM). Also inhibits IL-1 production in human monocytes (IC50 = 200 nM).
Potently inhibits p38 kinase (IC50 = 30 nM) and inhibits IL-1 production in human monocytes (IC50 = 200 nM).
生化/生理作用
Target IC50:30 nM and 200 nM against p38 kinase and IL-1 production, respectively, in human monocytes.
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.
储存分类代码
10-13 - German Storage Class 10 to 13
法规信息
新产品
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T F Gallagher et al.
Bioorganic & medicinal chemistry, 5(1), 49-64 (1997-01-01)
Members of three classes of pyridinylimidazoles bind with varying affinities to CSBP (p38) kinase which is a member of a stress-induced signal transduction pathway. Based upon SAR and protein homology modeling, the pharmacophore and three potential modes of binding to
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