assay
≥95% (HPLC)
form
solid
color
off-white
solubility
DMSO: 5 mg/mL
General description
A highly specific, cell-permeable, reversible, ATP-competitive, and potent inhibitor of p38 MAP kinase. Exhibits similar inhibitory potency as its parent compound SB 203580. Useful for the identification of inhibitor binding sites in p38 MAP kinase.
Biochem/physiol Actions
p38 MAP kinase
Preparation Note
Following initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
存储类别
10-13 - German Storage Class 10 to 13
法规信息
新产品
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L Tong et al.
Nature structural biology, 4(4), 311-316 (1997-04-01)
The crystal structure of human p38 mitogen-activated protein (MAP) kinase in complex with a potent and highly specific pyridinyl-imidazole inhibitor has been determined at 2.0 A resolution. The structure of the kinase, which is in its unphosphorylated state, is similar
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