565625
SC-68376 - CAS 318480-82-9 - Calbiochem
别名:
SC-68376 - CAS 318480-82-9 - Calbiochem, 2-Methyl-4-phenyl-5-(4-pyridyl)oxazole
assay
≥98% (HPLC)
form
semisolid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white to yellow
solubility
DMSO: 200 mg/mL
shipped in
ambient
Quality Level
General description
This product has been discontinued.
A potent, reversible, cell-permeable, ATP-competitive, and selective inhibitor of p38 MAP kinase activity in a dose-dependent manner (IC50 = 2-5 µM). Does not inhibit basal ERK or IL-1-induced JNK activity.
Potently, reversible, cell-permeable, ATP-competitive and selectively inhibits p38 mitogen-activated protein kinase (MAPK) activity in a dose-dependent manner (IC50 = 2-5 µM). Does not inhibit basal ERK or IL-1-induced JNK activity.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
p38MAPK
p38MAPK
Product competes with ATP.
Reversible: yes
Target IC50: 2-5 µM against p38MAP kinase activity
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Other Notes
Guan, Z., et al. 1998. J. Biol. Chem. 273, 12901.
Guan, Z., et al. 1997. J. Biol. Chem. 272, 8083.
Guan, Z., et al. 1997. J. Biol. Chem. 272, 8083.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
法规信息
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