质量水平
方案
≥97% (HPLC)
表单
solid
效能
10 nM IC50
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 2 mg/mL
运输
ambient
储存温度
2-8°C
InChI
1S/C20H20F2N2O4/c1-12(23-17(25)10-13-8-15(21)11-16(22)9-13)19(26)24-18(20(27)28-2)14-6-4-3-5-7-14/h3-9,11-12,18H,10H2,1-2H3,(H,23,25)(H,24,26)/t12-,18-/m0/s1
InChI key
XAPDRNSTUYCSQC-SGTLLEGYSA-N
一般描述
A cell-permeable γ-secretase inhibitor that inhibits Aβ secretion (IC50 ~10 nM) by 7PA2 cells (CHO cell line stably transfected with APP751 containing V717F familial Alzheimer′s disease mutation) in a dose-dependent manner. Also exhibits anti-aggregation properties by selectively blocking Aβ dimer and trimer formation and subsequently preventing early Aβ oligomerization.
生化/生理作用
Cell permeable: yes
Primary Target
γ-secretase Aβ₄₀ in 7PA2 cells
γ-secretase Aβ₄₀ in 7PA2 cells
Product does not compete with ATP.
Reversible: no
包装
Packaged under inert gas
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
其他说明
Walsh, D.M., et al. 2002. Nature 416, 535.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持