565791
γ-Secretase Inhibitor XXII , Aβ42-Selective, CS-1
The γ-Secretase Inhibitor XXII, Aβ42-Selective, CS-1, also referenced under CAS 1210283-33-2, controls the biological activity of γ-Secretase.
别名:
γ-Secretase Inhibitor XXII , Aβ42-Selective, CS-1, 3,3ʹ-(3,4,5-Trifluorophenyl)methylenebis-(4-hydroxycoumarin)
质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 50 mg/mL
运输
ambient
储存温度
2-8°C
一般描述
A cell-permeable di-coumarin compound that selectively inhibits γ-secretase-mediated production of Aβ42 over Aβ38, Aβ40, and Notch1 both in cell-free APP cleavage assays (IC50 = 0.07, 0.71, 0.31, and 1.77 µM, respectively) and in human and murine cultures (100% blockage of Aβ42 production and no effect against the rest at 30 µM) by altering the S1′ and S3′ pockets within the presenilin substrate binding site via an allosteric, non-substrate-competitive mechanism.
包装
Packaged under inert gas
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Shelton, C.C., et al. 2009. Proc. Natl. Acad. Sci. USA106, 20228.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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