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Merck
CN

566327

Sigma-Aldrich

SIRT1/2 Inhibitor VII

The SIRT1/2 Inhibitor VII, also referenced under CAS 143034-06-4, controls the biological activity of SIRT1/2. This small molecule/inhibitor is primarily used for Cell Structure applications.

别名:

SIRT1/2 Inhibitor VII, 5-(2-Naphthylidine)-2-thiobarbituric acid, SIRT1 Inhibitor V, SIRT2 Inhibitor VII

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关于此项目

经验公式（希尔记法）:
C15H10N2O2S
化学文摘社编号:
143034-06-4
分子量:
282.32
UNSPSC代码:
12352200

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质量水平

100

方案

≥95% (NMR)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

white to off-white

溶解性

DMSO: 3 mg/mL

运输

ambient

储存温度

2-8°C

一般描述

A thiobarbiturate compound that acts as an inhibitor against sirtuins (IC50 = 13.2 & 9.1 µM using human SIRT1 & SIRT2, respectively), the NAD+-dependent class III histone deacetylases (HDACs). Computer-aided molecular structural anaylsis reveals that both hydrogen bonds and van der Waals type of interactions contribute to the successful docking of the inhibitor into the nicotinamde subpocket of SIRT2 with the bulky naphthyl group being placed directly into the acetyllysine substrate channel.

包装

Packaged under inert gas

制备说明

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Uciechowska, U., et al. 2008. ChemMedChem3, 1965.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Standard Handling (A)

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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