S1P₁ Receptor Agonist, SEW2871 - CAS 256414-75-2 - Calbiochem

A cell-permeable oxadiazolothienyl compound that acts as a potent and highly selective S1P₁ agonist (EC₅₀ = 13 nM and 20.7 nM in GTPS1P_γ binding assay using human and murine S1P₁, respectively). Shown to induce S1P₁-mediated cellular functions in vitro and peripheral blood lymphopenia (oral ED₅₀ = 5.5 mg/kg) in mice in vivo. Unlike sphingosine-1-phosphate (Cat. No. 567727) and other known S1P receptor agonists, SEW2871 exhibits no activity towards other S1P receptor subtypes, S1P_2-5, even at concentrations as high as 10 µM.

A cell-permeable, potent, and highly selective S1P₁ agonist (EC₅₀ = 13 nM and 20.7 nM in GTPS1P_γ binding assay using human and murine S1P₁, respectively). Shown to induce S1P₁-mediated cellular functions in vitro and peripheral blood lymphopenia (oral ED₅₀ = 5.5 mg/kg) in mice in vivo. Unlike sphingosine-1-phosphate (Cat. No. 567727) and other known S1P receptor agonists, SEW2871 exhibits no activity towards other S1P receptor subtypes, S1P_2-5, even at concentrations as high as 10 µM.

Cell permeable: yes

EC50 = 13 nM and 20.7 nM in GTPS1Pγ binding assay using human and murine S1P1, respectively

Primary Target
S1P1 Receptor

Product does not compete with ATP.

Reversible: no

Packaged under inert gas

Sanna, M.G., et al. 2004. J. Biol. Chem.279, 13839.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Standard Handling (A)