567806
Src Kinase Inhibitor II
The Src Kinase Inhibitor II, also referenced under CAS 459848-35-2, controls the biological activity of Src Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
Src Kinase Inhibitor II
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
pale orange
solubility
DMSO: 20 mg/mL
shipped in
ambient
Quality Level
General description
A potent, selective, reversible, and ATP-competitive inhibitor of Src family tyrosine kinases (IC50 = 1.2 µM for human recombinant Csk). Exhibits little effect against p38 MAPK or FGFR tyrosine kinase even at concentrations as high as 50 µM.
A substituted triazoloquinoline-1-thione compound that acts as a potent, ATP-competitive, reversible and selective inhibitor of Src family tyrosine kinases (IC50 = 1.2 µM for human recombinant Csk). Exhibits little effect against p38 MAPK or FGFR even at concentrations as high as 50 µM.
Biochem/physiol Actions
Cell permeable: no
Primary Target
human recombinant Csk
human recombinant Csk
Product competes with ATP.
Reversible: yes
Target IC50: 1.2 µM for human recombinant Csk
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Kilimnik, A., et al. 2003. Cell. Mol. Biol. Lett.8, 588.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Carcinogenic / Teratogenic (D)
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持