567806
Src Kinase Inhibitor II
The Src Kinase Inhibitor II, also referenced under CAS 459848-35-2, controls the biological activity of Src Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
Src Kinase Inhibitor II
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About This Item
质量水平
方案
≥97% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
pale orange
溶解性
DMSO: 20 mg/mL
运输
ambient
储存温度
2-8°C
一般描述
A potent, selective, reversible, and ATP-competitive inhibitor of Src family tyrosine kinases (IC50 = 1.2 µM for human recombinant Csk). Exhibits little effect against p38 MAPK or FGFR tyrosine kinase even at concentrations as high as 50 µM.
A substituted triazoloquinoline-1-thione compound that acts as a potent, ATP-competitive, reversible and selective inhibitor of Src family tyrosine kinases (IC50 = 1.2 µM for human recombinant Csk). Exhibits little effect against p38 MAPK or FGFR even at concentrations as high as 50 µM.
生化/生理作用
Cell permeable: no
Primary Target
human recombinant Csk
human recombinant Csk
Product competes with ATP.
Reversible: yes
Target IC50: 1.2 µM for human recombinant Csk
包装
Packaged under inert gas
警告
Toxicity: Carcinogenic / Teratogenic (D)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Kilimnik, A., et al. 2003. Cell. Mol. Biol. Lett.8, 588.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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