572635
SU6656
A potent, cell-permeable, reversible, and ATP-competitive Src family kinase inhibitor.
别名:
SU6656
质量水平
方案
≥97% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
burnt orange
溶解性
DMSO: 25 mg/mL
运输
ambient
储存温度
−20°C
SMILES字符串
[S](=O)(=O)(N(C)C)c1cc2c(cc1)NC(=O)\C\2=C\c3[nH]c4c(c3)CCCC4
InChI
1S/C19H21N3O3S/c1-22(2)26(24,25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,3-6H2,1-2H3,(H,21,23)/b16-10+
InChI key
LOGJQOUIVKBFGH-MHWRWJLKSA-N
相关类别
一般描述
A potent, cell-permeable, reversible, and ATP-competitive Src family kinase inhibitor. Inhibits Src (IC50 = 280 nM) as well as closely related kinases such as Fyn (IC50 = 170 nM) and Yes (IC50 = 20 nM) and Lyn (IC50 = 130 nM). Acts as a weak inhibitor of Lck (IC50 = 688 µM) and PDGF receptor kinase (IC50 >10 µM). A 10 mM (500 µg/135 µl) solution of SU6656 (Cat. No. 572636) in DMSO is also available.
生化/生理作用
Cell permeable: yes
Product competes with ATP.
Reversible: yes
Target IC50: 280 nM, 170 nM, 20 nM, and 130 nM against Src, Fyn, Yes, and Lyn.
包装
Packaged under inert gas
其他说明
Bowman, T., et al. 2001. Proc. Natl. Acad. Sci. USA98, 7319.
Blake, R.A., et al. 2000. Mol. Cell. Biol.20, 9018.
Blake, R.A., et al. 2000. Mol. Cell. Biol.20, 9018.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Ning Wu et al.
Cell reports, 30(4), 1129-1140 (2020-01-30)
Plasma membrane damage and cell death during processes such as necroptosis and apoptosis result from cues originating intracellularly. However, death caused by pore-forming agents, like bacterial toxins or complement, is due to direct external injury to the plasma membrane. To
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