572635
SU6656
A potent, cell-permeable, reversible, and ATP-competitive Src family kinase inhibitor.
别名:
SU6656
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关于此项目
经验公式（希尔记法）:
C19H21N3O3S
化学文摘社编号:
分子量:
371.45
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
[S](=O)(=O)(N(C)C)c1cc2c(cc1)NC(=O)\C\2=C\c3[nH]c4c(c3)CCCC4
InChI
1S/C19H21N3O3S/c1-22(2)26(24,25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,3-6H2,1-2H3,(H,21,23)/b16-10+
InChI key
LOGJQOUIVKBFGH-MHWRWJLKSA-N
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
burnt orange
solubility
DMSO: 25 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
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General description
A potent, cell-permeable, reversible, and ATP-competitive Src family kinase inhibitor. Inhibits Src (IC50 = 280 nM) as well as closely related kinases such as Fyn (IC50 = 170 nM) and Yes (IC50 = 20 nM) and Lyn (IC50 = 130 nM). Acts as a weak inhibitor of Lck (IC50 = 688 µM) and PDGF receptor kinase (IC50 >10 µM). A 10 mM (500 µg/135 µl) solution of SU6656 (Cat. No. 572636) in DMSO is also available.
Biochem/physiol Actions
Cell permeable: yes
Product competes with ATP.
Reversible: yes
Target IC50: 280 nM, 170 nM, 20 nM, and 130 nM against Src, Fyn, Yes, and Lyn.
Packaging
Packaged under inert gas
Other Notes
Bowman, T., et al. 2001. Proc. Natl. Acad. Sci. USA98, 7319.
Blake, R.A., et al. 2000. Mol. Cell. Biol.20, 9018.
Blake, R.A., et al. 2000. Mol. Cell. Biol.20, 9018.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Ning Wu et al.
Cell reports, 30(4), 1129-1140 (2020-01-30)
Plasma membrane damage and cell death during processes such as necroptosis and apoptosis result from cues originating intracellularly. However, death caused by pore-forming agents, like bacterial toxins or complement, is due to direct external injury to the plasma membrane. To
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